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Antitumor activity of molecular-targeted agents is guided by the presence of documented genomic alteration in specific histological subtypes. We aim to explore the feasibility, efficacy and (...)
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This chapter “Approaching the Public by Social Worlds : Understanding Bloggers’ Taste” places us in a distinct world of the media : the world of the public. The title aims to highlight two aspects (...)
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PURPOSE : Lack of physical activity (PA), weight gain, and overweight have been associated with increased risk of recurrence and mortality after breast cancer diagnosis. We evaluated the (...)
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The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the (...)
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Purpose/Objective(s) Breast cancer (BC) patients with comparable prognostic features have heterogeneous outcomes, partly because of radiotherapy resistance leading to loco-regional recurrences (...)
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The mammalian target of rapamycin complex 1 (mTORC1) is an attractive target for HER-2 positive breast cancer therapy because of its key role in protein translation regulation, cell growth and (...)
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Background : Breast cancer (BC) patients with comparable prognostic features have heterogeneous outcomes, party related to a possible radiotherapy resistance leading to local-regional recurrences (...)
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Patients with metastatic breast cancer (MBC) represent a heterogeneous group, with large differences in outcomes from individual patients. VE-cadherin, an endothelial-specific cadherin, was shown (...)
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BACKGROUND : Several studies used the ratio of progression-free survival (PFS) on genotype-matched treatment to PFS on genotype-unmatched treatment to assess the efficacy of therapy guided by (...)
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Simulating human-centered pervasive systems requires accurate assumptions on the behavior of human groups. Recent models consider this behavior as a combination of both social and spatial (...)
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The recent thriving development of biobanks and associated high-throughput phenotyping studies requires the elaboration of large-scale approaches for monitoring biological sample quality and (...)
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BACKGROUND : Maintenance strategies beyond response or tumor stabilization with first-line chemotherapy in metastatic breast cancer (MBC) have not been extensively studied. Endocrine therapy (...)
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Many advances in recent years, such as the use of targeted therapies, have enabled to improve the management of cancer patients. Understanding the effect of targeted therapies on the human (...)
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BACKGROUND : Several expression array studies identified molecular apocrine breast cancer (BC) as a subtype that expresses androgen receptor (AR) but not estrogen receptor alpha. We carried out a (...)
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The poor outcome of patients with recurrent ovarian cancer constitutes a continuous challenge for decision-making in clinical practice. In this setting, molecular targets have recently been (...)
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Monitoring functional competence of immune cell populations in clinical routine represents a major challenge. We developed a whole-blood assay to monitor functional competence of peripheral (...)
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Malgré les bénéfices reconnus, inciter des patients atteints de cancer à intégrer un programme d’activité physique (AP) reste complexe, et l’information transmise peut être inappropriée selon le profil (...)
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Cet article présente un cadre conceptuel à l’interface des dimensions physiologiques et psychologiques (le ’syndrome des 3H’ ou processus de ’sédentarisme’) permettant de rendre compte des processus de (...)
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HER2-positive breast cancer has long proven to be a clinically distinct class of breast cancers for which several targeted therapies are now available. However, resistance to the treatment (...)
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Background : Renal cell carcinoma is one of the most chemoresistant cancers, and its metastatic form requires administration of targeted therapies based on angiogenesis or mTOR inhibitors. (...)
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Solid tumors require blood vessels for growth, and many new cancer therapies are directed against the tumor vasculature. Antiangiogenic therapies should destroy the tumor vasculature, thereby (...)
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Hormone-dependent breast cancer is the first example of cancer treated by targeted therapy for more than 30 years. Blocking estrogen pathway was the first therapeutical strategy for this subtype (...)
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BACKGROUND : Neoadjuvant trials conducted using a double HER2 blockade with lapatinib and trastuzumab, combined with different paclitaxel-containing chemotherapy regimens, have shown high (...)
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This paper presents a methodology to guide the evaluation of social distributed applications in mobile environments. Even when applications are already designed, they exhibit a number of tuning (...)
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Breast cancer (BC) displays a high heterogeneity from histology to prognosis, metastatic evolution and treatment responses. We report here a (1)H NMR-based metabolic phenotyping study aiming at (...)
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L’imaginaire collective oppose le Web 1.0 à la vague du Web 2.0, apparue à partir du milieu des années 2000. Schématiquement, une ère où dominerait la production des contenus des utilisateurs (...)
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Simulating human-centered pervasive systems requires accurate assumptions on the behavior of human groups. Recent models consider this behavior as a combination of both social and spatial (...)
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BACKGROUND : Cancer patients with CD4 lymphopenia have an increased risk of severe toxicity after administration of cytotoxic chemotherapy. The impact of CD4 lymphopenia on long term overall (...)
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Personalized medicine is defined by the National Cancer Institute as "a form of medicine that uses information about a person’s genes, proteins, and environment to prevent, diagnose, and (...)
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Overexpression of the ErbB2 receptor tyrosine kinase in breast cancer contributes to tumor development and is associated with poor prognosis. However, the mechanism by which ErbB2 might (...)
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Lymphopenia (< 1Giga/L) detected before initiation of chemotherapy is a predictive factor for death in metastatic solid tumors. Combinatorial T cell repertoire (TCR) diversity was investigated (...)
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Hormonal dependence of breast cancer has been known for a long time, yet about half of breast cancers with estrogen receptor will not respond to antihormonal therapy. Now, we know that this (...)
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OBJECTIVES. As vascular endothelial growth factor (VEGF) is expressed in ovarian cancer, we assessed the efficacy and safety of bevacizumab (a monoclonal antibody targeting VEGF) plus microtubule (...)
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In ovarian cancer, the immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment. In this study, we investigated the (...)
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Although new chemotherapeutic drugs for metastatic breast cancer (MBC) have been approved over the past decade, it is unclear whether this has changed the overall outcome of patients. This study (...)
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The large subunit of human ribonucleotide reductase, RRM1, is involved in the regulation of cell proliferation, cell migration, tumour and metastasis development, and the synthesis of (...)
Olivier Trédan