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Benefits of physical activity are widely demonstrated for early stage cancers but few studies have focused on metastatic disease. The purpose of this study was to determine the impact of physical (...)
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A total of 76 patients were enrolled in this retrospective monocentric study. All patients had a non-metastatic triple negative breast cancer and underwent a pre-therapeutic MRI protocol (...)
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Rapalogs have become standard-of-care in patients with metastatic breast, kidney, and neuroendocrine cancers. Nevertheless, tumor escape occurs after several months in most patients, highlighting (...)
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Proof of concept studies has reported that circulating endothelial cell (CEC) count may be associated with the outcome of HER2-negative metastatic breast cancer (mBC) patients treated by (...)
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Dendritic cells play a key role in the orchestration of antitumor immune responses. The cDC1 (conventional dendritic cell 1) subset has been shown to be essential for antitumor responses and (...)
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PURPOSE Adverse effects of breast cancer treatment can negatively affect survivors’ work ability. Previous reports lacked detailed clinical data or health-related patient-reported outcomes (PROs) (...)
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Antitumor activity of molecular-targeted agents is guided by the presence of documented genomic alteration in specific histological subtypes. We aim to explore the feasibility, efficacy and (...)
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This chapter “Approaching the Public by Social Worlds : Understanding Bloggers’ Taste” places us in a distinct world of the media : the world of the public. The title aims to highlight two aspects (...)
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PURPOSE : Lack of physical activity (PA), weight gain, and overweight have been associated with increased risk of recurrence and mortality after breast cancer diagnosis. We evaluated the (...)
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The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the (...)
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Purpose : Leptomeningeal carcinomatosis (MC) is commonly associated with HER2-positive breast cancer (HER2-BC), with a poor prognosis and no standardised treatment. We conducted a phase I (...)
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Les auteurs interrogent la manière dont des changements organisationnels basés sur le rationalisme économique peuvent avoir des répercussions sur les procès de production de l’information hyperlocale (...)
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The mammalian target of rapamycin complex 1 (mTORC1) is an attractive target for HER-2 positive breast cancer therapy because of its key role in protein translation regulation, cell growth and (...)
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Purpose/Objective(s) Breast cancer (BC) patients with comparable prognostic features have heterogeneous outcomes, partly because of radiotherapy resistance leading to loco-regional recurrences (...)
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Background : Breast cancer (BC) patients with comparable prognostic features have heterogeneous outcomes, party related to a possible radiotherapy resistance leading to local-regional recurrences (...)
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Patients with metastatic breast cancer (MBC) represent a heterogeneous group, with large differences in outcomes from individual patients. VE-cadherin, an endothelial-specific cadherin, was shown (...)
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The recent thriving development of biobanks and associated high-throughput phenotyping studies requires the elaboration of large-scale approaches for monitoring biological sample quality and (...)
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BACKGROUND : Several studies used the ratio of progression-free survival (PFS) on genotype-matched treatment to PFS on genotype-unmatched treatment to assess the efficacy of therapy guided by (...)
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Simulating human-centered pervasive systems requires accurate assumptions on the behavior of human groups. Recent models consider this behavior as a combination of both social and spatial (...)
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BACKGROUND : Maintenance strategies beyond response or tumor stabilization with first-line chemotherapy in metastatic breast cancer (MBC) have not been extensively studied. Endocrine therapy (...)
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Many advances in recent years, such as the use of targeted therapies, have enabled to improve the management of cancer patients. Understanding the effect of targeted therapies on the human (...)
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BACKGROUND : Several expression array studies identified molecular apocrine breast cancer (BC) as a subtype that expresses androgen receptor (AR) but not estrogen receptor alpha. We carried out a (...)
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Monitoring functional competence of immune cell populations in clinical routine represents a major challenge. We developed a whole-blood assay to monitor functional competence of peripheral (...)
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The poor outcome of patients with recurrent ovarian cancer constitutes a continuous challenge for decision-making in clinical practice. In this setting, molecular targets have recently been (...)
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HER2-positive breast cancer has long proven to be a clinically distinct class of breast cancers for which several targeted therapies are now available. However, resistance to the treatment (...)
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Cet article présente un cadre conceptuel à l’interface des dimensions physiologiques et psychologiques (le ’syndrome des 3H’ ou processus de ’sédentarisme’) permettant de rendre compte des processus de (...)
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Malgré les bénéfices reconnus, inciter des patients atteints de cancer à intégrer un programme d’activité physique (AP) reste complexe, et l’information transmise peut être inappropriée selon le profil (...)
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Background : Renal cell carcinoma is one of the most chemoresistant cancers, and its metastatic form requires administration of targeted therapies based on angiogenesis or mTOR inhibitors. (...)
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Solid tumors require blood vessels for growth, and many new cancer therapies are directed against the tumor vasculature. Antiangiogenic therapies should destroy the tumor vasculature, thereby (...)
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Hormone-dependent breast cancer is the first example of cancer treated by targeted therapy for more than 30 years. Blocking estrogen pathway was the first therapeutical strategy for this subtype (...)
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BACKGROUND : Neoadjuvant trials conducted using a double HER2 blockade with lapatinib and trastuzumab, combined with different paclitaxel-containing chemotherapy regimens, have shown high (...)
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Les pratiques amateur, foisonnantes et hétéroclites, restent largement méconnues, en particulier dans le domaine des médias et du journalisme, alors qu’elles représentent bien souvent une part (...)
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This paper presents a methodology to guide the evaluation of social distributed applications in mobile environments. Even when applications are already designed, they exhibit a number of tuning (...)
Olivier Trédan